Ace the 2025 ATI Pathophysiology Test – Dive Into Disease with Confidence!

The most common cause of chronic kidney disease (CKD) is diabetes mellitus. This condition leads to CKD primarily through the mechanism of diabetic nephropathy, which is a complication seen in individuals with long-standing uncontrolled diabetes. High blood sugar levels can damage the blood vessels in the kidneys over time, leading to decreased kidney function. Diabetic nephropathy typically progresses through stages, starting with hyperfiltration and glomerular hypertrophy, eventually leading to reduced glomerular filtration rate (GFR) and the development of end-stage renal disease (ESRD) if not managed effectively.

In addition to damage to the renal vasculature, diabetes can cause alterations in glomerular structure and function, which further contributes to the decline in kidney function. Managing diabetes through lifestyle changes and medications can help prevent or slow the progression of CKD, highlighting the critical role of glucose control in preventing kidney damage.

While hypertension is also a significant factor contributing to CKD and can often coexist with diabetes, it is generally considered a consequence of diabetes rather than the primary cause. Glomerulonephritis and polycystic kidney disease contribute to CKD but occur with less frequency compared to the prevalence of diabetic-related kidney damage. Therefore, understanding